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Management of intraductal papillary mucinous neoplasm of the pancreas
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Management of intraductal papillary mucinous neoplasm of the pancreas
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Journal Article
Management of intraductal papillary mucinous neoplasm of the pancreas
2008
Overview
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a distinct entity characterized by papillary proliferations of mucin-producing epithelial cells with excessive mucus production and cystic dilatation of the pancreatic ducts. IPMNs have malignant potential and exhibit a broad histologic spectrum, ranging from adenoma to invasive carcinoma. IPMNs are classified into main duct and branch duct types, based on the site of tumor involvement. IPMN patients have a favorable prognosis if appropriately treated. The postoperative 5-year survival rate is nearly 100% for benign tumors and noninvasive carcinoma, and approximately 60% for invasive carcinoma. A main duct type IPMN should be resected. Surgical treatment is indicated for a branch duct IPMN with suspected malignancy (tumor diameter ≥ 30 mm, mural nodules, dilated main pancreatic duct, or positive cytology) or positive symptoms. Malignant IPMNs necessitate lymph node dissection (D1). IPMNs are associated with a high incidence of extrapancreatic malignancies and pancreatic ductal carcinoma.
Publisher
Springer Japan,Springer Nature B.V
Subject
/ Adenocarcinoma, Mucinous - diagnosis
/ Adenocarcinoma, Mucinous - pathology
/ Adenocarcinoma, Mucinous - surgery
/ Aged
/ Carcinoma, Pancreatic Ductal - diagnosis
/ Carcinoma, Pancreatic Ductal - pathology
/ Carcinoma, Pancreatic Ductal - surgery
/ Carcinoma, Papillary - diagnosis
/ Carcinoma, Papillary - pathology
/ Carcinoma, Papillary - surgery
/ Female
/ Humans
/ intraductal papillary mucinous neoplasm
/ Male
/ Medicine
/ Pancreatic Neoplasms - diagnosis
/ Pancreatic Neoplasms - pathology
/ Pancreatic Neoplasms - surgery
/ Review
