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Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children

by Nyirenda, Osward M , Kotloff, Karen , Gordon, Melita A , Gmeiner, Markus , Meiring, James E , Dube, Queen , Neuzil, Kathleen M , Masesa, Clemens , Kawalazira, Gift , Liang, Yuanyuan , Mbewe, Maurice , Rotrosen, Elizabeth , Patel, Priyanka D , Banda, David , Patel, Pratiksha , Simiyu, Kenneth , Misiri, Theresa , Tracy, J. Kathleen , Laurens, Matthew B , Henrion, Marc , Msuku, Harrison , Mwakiseghile, Felistas , Nampota, Nginache , Adetunji, Fiyinfolu , Birkhold, Megan , Heyderman, Robert S

in Adverse events / Age / Antimicrobial agents / Bacterial Infections / Blood culture / Childhood Diseases / Children / Consortia / Drug resistance / Fatalities / Fever / Global Health / Health facilities / Hospitals / Illnesses / Immunization / Infectious Disease / Multidrug resistance / Pediatrics / Polysaccharides / Public health / Salmonella / Surveillance / Tropical diseases / Typhoid / Vaccination / Vaccine efficacy / Vaccines

2021

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Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children

2021

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2021

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Journal Article

Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children

Nyirenda, Osward M,

Kotloff, Karen,

Gordon, Melita A,

Gmeiner, Markus,

Meiring, James E,

Dube, Queen,

Neuzil, Kathleen M,

Masesa, Clemens,

Kawalazira, Gift,

Liang, Yuanyuan,

Mbewe, Maurice,

Rotrosen, Elizabeth,

Patel, Priyanka D,

Banda, David,

Patel, Pratiksha,

Simiyu, Kenneth,

Misiri, Theresa,

Tracy, J. Kathleen,

Laurens, Matthew B,

Henrion, Marc,

Msuku, Harrison,

Mwakiseghile, Felistas,

Nampota, Nginache,

Adetunji, Fiyinfolu,

Birkhold, Megan,

Heyderman, Robert S

2021

Overview

The efficacy of a Vi polysaccharide typhoid conjugate vaccine (Vi-TCV) was assessed in 28,130 Malawian children who were 9 months to 12 years of age. The incidence of blood culture–confirmed typhoid fever was significantly lower among children who received Vi-TCV than among those who received a control vaccine.

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Publisher

Massachusetts Medical Society

Subject

Adverse events

/ Age

/ Antimicrobial agents

/ Bacterial Infections

/ Blood culture

/ Childhood Diseases

/ Children