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Apoptin Induces Apoptosis in Human Transformed and Malignant Cells but not in Normal Cells
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Apoptin Induces Apoptosis in Human Transformed and Malignant Cells but not in Normal Cells
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Journal Article
Apoptin Induces Apoptosis in Human Transformed and Malignant Cells but not in Normal Cells
1997
Overview
The chicken anemia virus protein apoptin induces a p53-independent, Bcl-2-insensitive type of apoptosis in various human tumor cells. Here, we show that, in vitro, apoptin fails to induce programmed cell death in normal lymphoid, dermal, epidermal, endothelial, and smooth-muscle cells. However, when normal cells are transformed they become susceptible to apoptosis by apoptin. Long-term expression of apoptin in normal human fibroblasts revealed that apoptin has no toxic or transforming activity in these cells. In normal cells, apoptin was found predominantly in the cytoplasm, whereas in transformed and malignant cells it was located in the nucleus, suggesting that the localization of apoptin is related to its activity. These properties make apoptin a potential agent for the treatment of a large number of tumors, also those lacking p53 and/or overexpressing Bcl-2.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences,National Academy of Sciences,The National Academy of Sciences of the USA
Subject
/ Cancer
/ Cell Transformation, Neoplastic
/ Chicken anemia virus - genetics
/ Chicken anemia virus - physiology
/ Diploidy
/ Fluorescent Antibody Technique, Indirect
/ Human umbilical vein endothelial cells
/ Humans
/ Male
/ Recombinant Proteins - analysis
/ Recombinant Proteins - biosynthesis
/ Skin Physiological Phenomena
/ Tumors
