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Monocyte Subtypes Predict Clinical Course and Prognosis in Human Stroke
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Monocyte Subtypes Predict Clinical Course and Prognosis in Human Stroke
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Journal Article
Monocyte Subtypes Predict Clinical Course and Prognosis in Human Stroke
2009
Overview
The number of circulating monocytes increases after stroke. In this study, we assessed the time course and phenotype of monocyte subsets and their relationship with the clinical course and outcome in 46 consecutive stroke patients and 13 age-matched controls. The proportion of the most abundant ‘classical’ CD14highCD16 monocytes did not change after stroke, whereas that of CD14highCD16+ monocytes increased and CD14dimCD16+ monocytes decreased. CD14highCD16 + monocytes had the highest expression of TLR2, HLA-DR and the angiogenic marker, Tie-2; CD14dimCD16+ monocytes had the highest expression of costimulatory CD86 and adhesion molecule CD49d. Platelet-monocyte interactions were highest in CD14highCD16 monocytes and lowest in CD14dimCD16+ monocytes. In adjusted models, 1/CD14highCD16 monocytes were associated with poor outcome (OR: 1.38), higher mortality (OR: 1.40) and early clinical worsening (OR: 1.29); 2/CD14highCD16+ monocytes were inversely related to mortality (OR: 0.32); and 3/CD14dimCD16+ monocytes were inversely related to poor outcome (OR: 0.74) and infarction size (r= 0.45; P = 0.02). These results illustrate that the predominant monocyte subtype conveys harmful effects after stroke, which include stronger interaction with platelets. Alternatively, rarer subpopulations of monocytes are beneficial with a phenotype that could promote tissue repair and angiogenesis. Therefore, monitoring of monocyte subtypes may emerge as a useful tool at the bedside for stroke patients.
Publisher
SAGE Publications,Nature Publishing Group,Sage Publications Ltd
Subject
/ Biological and medical sciences
/ Blood Platelets - immunology
/ Female
/ Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
/ Humans
/ Lipopolysaccharide Receptors - biosynthesis
/ Male
/ Neovascularization, Physiologic - immunology
/ Nervous system (semeiology, syndromes)
/ Receptors, IgG - biosynthesis
/ Vascular diseases and vascular malformations of the nervous system
