Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

by Coote, Jim E , Prinjha, Rab K , Bingham, Ryan P , Craggs, Peter D , Yao, Gang , Lind, Kenneth E , Davis, Rob P , Maller, Claire , Bicker, Kevin L , Joberty, Gerard , Thompson, Paul R , Martinod, Kimberly , Sheppard, Robert J , Lewis, Huw D , Rüdiger, Martin , Rise, Cecil E , Bax, Benjamin D , Campbell, Matthew , Polyakova, Oxana , Drewes, Gerard , Eberhard, Dirk , Barker, Michael D , Locke, Kelly , Wilson, David M , Thorpe, Jim , Liddle, John , Patten, Chris , Chen, Yu Hua , Chung, Chun-wa , Wagner, Denisa D , Thomas, Pamela , Atkinson, Stephen J , Slade, Daniel J

in 101/58 / 13 / 14 / 631/250 / 631/535 / 631/92/613 / 82/51 / 82/80 / Animals / Benzimidazoles - chemical synthesis / Benzimidazoles - pharmacology / Binding, Competitive / Biochemical Engineering / Biochemistry / Bioorganic Chemistry / brief-communication / Calcium - metabolism / Cell Biology / Chemistry / Chemistry/Food Science / Citrulline - metabolism / Enzyme Inhibitors - chemical synthesis / Enzyme Inhibitors - pharmacology / Genetics / HEK293 Cells / Histones - metabolism / Humans / Hydrolases - antagonists & inhibitors / In Vitro Techniques / Mice / Models, Molecular / Neutrophils - drug effects / Protein-Arginine Deiminases / Small Molecule Libraries / Substrate Specificity

2015

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

2015

Confirm

Do you wish to request the book?

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

2015

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Coote, Jim E,

Prinjha, Rab K,

Bingham, Ryan P,

Craggs, Peter D,

Yao, Gang,

Lind, Kenneth E,

Davis, Rob P,

Maller, Claire,

Bicker, Kevin L,

Joberty, Gerard,

Thompson, Paul R,

Martinod, Kimberly,

Sheppard, Robert J,

Lewis, Huw D,

Rüdiger, Martin,

Rise, Cecil E,

Bax, Benjamin D,

Campbell, Matthew,

Polyakova, Oxana,

Drewes, Gerard,

Eberhard, Dirk,

Barker, Michael D,

Locke, Kelly,

Wilson, David M,

Thorpe, Jim,

Liddle, John,

Patten, Chris,

Chen, Yu Hua,

Chung, Chun-wa,

Wagner, Denisa D,

Thomas, Pamela,

Atkinson, Stephen J,

Slade, Daniel J

2015

Overview

Inhibitors of the PAD4 enzyme that bind the inactive enzyme link this protein deiminase and the resultant arginine-to-citrulline modification to formation of neutrophil extracellular traps, highly decondensed chromatin structures with both host-defense and pathological roles. PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

101/58

/ 13

/ 14

/ 631/250

/ 631/535

/ 631/92/613

/ 82/51