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The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial
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The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial
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Journal Article
The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial
2017
Overview
The aim of this study was to investigate the effects of three
Lactobacillus plantarum
strains on
in-vivo
small intestinal barrier function and gut mucosal gene transcription in human subjects. The strains were selected for their differential effects on TLR signalling and tight junction protein rearrangement, which may lead to beneficial effects in a stressed human gut mucosa. Ten healthy volunteers participated in four different intervention periods: 7-day oral intake of either
L. plantarum
WCFS1, CIP104448, TIFN101 or placebo, proceeded by a 4 weeks wash-out period. Lactulose-rhamnose ratio (an indicator of small intestinal permeability) increased after intake of indomethacin, which was given as an artificial stressor of the gut mucosal barrier (mean ratio 0.06 ± 0.04 to 0.10 ± 0.06,
p
= 0.001), but was not significantly affected by the bacterial interventions. However, analysis in small intestinal biopsies, obtained by gastroduodenoscopy, demonstrated that particularly
L. plantarum
TIFN101 modulated gene transcription pathways related to cell-cell adhesion with high turnover of genes involved in tight- and adhesion junction protein synthesis and degradation (
e.g.
actinin alpha-4, metalloproteinase-2). These effects were less pronounced for
L. plantarum
WCFS1 and CIP104448. In conclusion,
L. plantarum
TIFN101 induced the most pronounced probiotic properties with specific gene transcriptional effects on repair processes in the compromised intestine of healthy subjects.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Actinin
/ Adhesion
/ Chair Nutrition Metabolism and Genomics
/ FBR Consumer Science & Health
/ Food, Health & Consumer Research
/ HNE Nutrition, Metabolism and Genomics
/ HNE Voeding, Metabolisme en Genomics
/ Humanities and Social Sciences
/ Mucosa
/ Nutrition, Metabolism and Genomics
/ Rhamnose
/ Science
/ VLAG
