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Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique
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Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique
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Journal Article
Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique
2010
Overview
Here we applied a magnetic force-based tissue engineering technique to cardiac tissue fabrication. A mixture of extracellular matrix precursor and cardiomyocytes labeled with magnetic nanoparticles was added into a well containing a central polycarbonate cylinder. With the use of a magnet, the cells were attracted to the bottom of the well and allowed to form a cell layer. During cultivation, the cell layer shrank towards the cylinder, leading to the formation of a ring-shaped tissue that possessed a multilayered cell structure and contractile properties. These results indicate that magnetic tissue fabrication is a promising approach for cardiac tissue engineering.
Publisher
MDPI AG,Molecular Diversity Preservation International (MDPI)
