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New molecular components of high and low affinity iron import systems in Drosophila
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New molecular components of high and low affinity iron import systems in Drosophila
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New molecular components of high and low affinity iron import systems in Drosophila
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Journal Article
New molecular components of high and low affinity iron import systems in Drosophila
2025
Overview
The high abundance and molecular versatility of iron have led to its universal presence in biological systems, yet its absorption is exceptionally challenging. Animals and yeasts use divalent metal transporters to import iron, but yeasts also employ the multicopper oxidase Fet3p for high-affinity iron uptake when iron-starved. Using long-term iron depletion in
Drosophila
, we identified four components involved in iron absorption: Multicopper oxidase-4 (Mco4), a Fet3p ortholog, is essential for surviving iron starvation, whereas the cytochrome b561 enzymes Fire (Ferric Iron Reductase) and Fire-like, as well as cytochrome b5 protein Firewood, are required for iron absorption under normal conditions. This study reports the presence of a high-affinity iron uptake system in an animal, a cytochrome b5 electron donor for ferric iron reduction, and intestinal ferric reductases, and provides a valuable resource for further exploration of genes involved in iron homeostasis, transport, and absorption.
Although iron is essential, its absorption is inefficient; this study uncovers distinct iron uptake strategies in
Drosophila
, including a previously unrecognized high-affinity system activated during iron starvation.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/89
/ 14/1
/ 14/19
/ 49/91
/ 64/24
/ 82/58
/ 82/80
/ Affinity
/ Animals
/ Biology
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - metabolism
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Genes
/ Genomes
/ Humanities and Social Sciences
/ Imports
/ Insects
/ Iron
/ Oxidase
/ Oxidoreductases - metabolism
/ Proteins
/ RNAi
/ Science
/ Yeast
