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Concise Review: Stem Cell Therapy for Stroke Patients: Are We There Yet?
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Journal Article
Concise Review: Stem Cell Therapy for Stroke Patients: Are We There Yet?
2019
Overview
Four decades of preclinical research demonstrating survival, functional integration, and behavioral effects of transplanted stem cells in experimental stroke models have provided ample scientific basis for initiating limited clinical trials of stem cell therapy in stroke patients. Although safety of the grafted cells has been overwhelmingly documented, efficacy has not been forthcoming. Two recently concluded stroke clinical trials on mesenchymal stem cells (MSCs) highlight the importance of strict adherence to the basic science findings of optimal transplant regimen of cell dose, timing, and route of delivery in enhancing the functional outcomes of cell therapy. Echoing the Stem Cell Therapeutics as an Emerging Paradigm for Stroke and Stroke Treatment Academic Industry Roundtable call for an NIH‐guided collaborative consortium of multiple laboratories in testing the safety and efficacy of stem cells and their derivatives, not just as stand‐alone but preferably in combination with approved thrombolytic or thrombectomy, may further increase the likelihood of successful fruition of translating stem cell therapy for stroke clinical application. The laboratory and clinical experience with MSC therapy for stroke may guide the future translational research on stem cell‐based regenerative medicine in neurological disorders. Stem Cells Translational Medicine 2019;8:983&988
Lab‐to‐clinic translation of stem cell therapy for stroke. Basic science discoveries have implicated putative mechanisms of action of stem cells, including cell replacement of infarcted or ischemic cells, by‐stander effects such as secretion of growth factors or anti‐inflammatory substances, and transfer of cell components like mitochondria, microvesicles, and microRNAs. These regenerative mechanisms can also be used to prescreen viable and transplantable cells prior to transplantation, as well as to serve as potency assays to monitor stem cell functional status following their transplantation into the ischemic stroke brain.
Publisher
John Wiley & Sons, Inc,Oxford University Press
Subject
