Journal Article

Selection and characterization of tenascin C targeting peptide

Lee, H.R., University of Ulsan College of Medicine, Seoul, Republic of Korea, Park, K.R., Jooseong College, Cheongwon, Republic of Korea, Kang, K.W., Seoul National University College of Medicine, Seoul, Republic of Korea, Jeong, S.J., Dankook University, Yongin, Republic of Korea, Lee, C.T., Seoul National University College of Medicine, Seoul, Republic of Korea, Choi, Y.S., Dankook University, Yongin, Republic of Korea, Kim, M.Y., Dankook University, Yongin, Republic of Korea, Kim, O.R., Dankook University, Yongin, Republic of Korea

2012

Overview

Since tenascin C is a factor expressed highly in the tumor-associated matrix, it would be a desirable first step for targeting the tumor-specific microenvironment. In fact, a high level of tenascin C expression has been reported in most solid tumors, including lung cancer, colon cancer and glioblastoma. Therefore, the targeted binding of tenascin C in tumor stroma would inhibit tumor metastasis by modulating cancer cell growth and migration. We isolated a peptide that bound to tenascin C by phage display peptide library selection, and the selected peptide specifically recognized tenascin C protein in xenograft mouse tissue. We also observed exclusive staining of tenascin C by the selected peptide in tumor patient tissues. Moreover, the peptide reduced tenascin C-induced cell rounding and migration. We propose that the tenascin C targeting peptide may be useful as a specific anti-cancer diagnostic and therapeutic tool for most human solid tumors.

• Publisher: Korean Society for Molecular and Cellular Biology,Korea Society for Molecular and Cellular Biology,한국분자세포생물학회
• Subject: anti-cancer therapeutic / Biochemistry / Biomedical and Life Sciences / Biomedicine / Biotechnology / Cell Biology / Life Sciences / PEPTIDE / PEPTIDES / PEPTIDOS / tenascin C / 생물학