Asset Details
Do you wish to reserve the book?
Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism
Do you wish to request the book?
Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Effects of smoking on cognition and BDNF levels in a male Chinese population: relationship with BDNF Val66Met polymorphism
2019
Overview
Recent studies demonstrate that brain-derived neurotrophic factor (BDNF) might be associated with nicotine addiction, and circulating BDNF is a biomarker of memory and general cognitive function. Moreover, studies suggest that a functional polymorphism of the
BDNF
Val66Met may mediate hippocampal-dependent cognitive functions. We aimed to explore the relationships between smoking, cognitive performance and BDNF in a normal Chinese Han population. We recruited 628 male healthy subjects, inducing 322 smokers and 306 nonsmokers, and genotyped them the
BDNF
Val66Met polymorphism. Of these, we assessed 114 smokers and 98 nonsmokers on the repeatable battery for the assessment of neuropsychological status (RBANS), and 103 smokers and 89 nonsmokers on serum BDNF levels. Smokers scored lower than the nonsmokers on RBANS total score (p = 0.002), immediate memory (p = 0.003) and delayed memory (p = 0.021). BDNF levels among the smokers who were Val allele carriers were correlated with the degree of cognitive impairments, especially attention, as well as with the carbon monoxide concentrations. Our findings suggest that smoking is associated with cognitive impairment in a male Chinese Han population. The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the
BDNF Val66Met
polymorphism.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/44
/ Adult
/ Aged
/ Alleles
/ Asian Continental Ancestry Group - genetics
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - genetics
/ Brain-Derived Neurotrophic Factor - metabolism
/ Cognition Disorders - genetics
/ Cognition Disorders - physiopathology
/ Cognitive Dysfunction - genetics
/ Cognitive Dysfunction - physiopathology
/ Genetic Predisposition to Disease
/ Genotype
/ Humanities and Social Sciences
/ Humans
/ Male
/ Memory
/ Nicotine
/ Polymorphism, Single Nucleotide - genetics
/ Science
/ Smoking
