Asset Details
Do you wish to reserve the book?
Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
Do you wish to request the book?
Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
2019
Overview
Arterial stiffness index (ASI) is a non-invasive measure of arterial stiffness using infra-red finger sensors (photoplethysmography). It is a well-suited measure for large populations as it is relatively inexpensive to perform, and data can be acquired within seconds. These features raise interest in using ASI as a tool to estimate cardiovascular disease risk as prior work demonstrates increased arterial stiffness is associated with elevated systolic blood pressure, and ASI is predictive of cardiovascular disease and mortality. We conducted genome-wide association studies (GWASs) for ASI in 127,121 UK Biobank participants of European-ancestry. Our primary analyses identified variants at four loci reaching genome-wide significance (
P
< 5 × 10
−8
):
TEX41
(rs1006923;
P
= 5.3 × 10
−12
),
FOXO1
(rs7331212;
P
= 2.2 × 10
−11
),
C1orf21
(rs1930290,
P
= 1.1 × 10
−8
) and
MRVI1
(rs10840457,
P
= 3.4 × 10
−8
). Gene-based testing revealed three significant genes, the most significant gene was
COL4A2
(
P
= 1.41 × 10
−8
) encoding type IV collagen. Other candidate genes at associated loci were also involved in smooth muscle tone regulation. Our findings provide new information for understanding the development of arterial stiffness.
Publisher
Nature Publishing Group UK,Nature Publishing Group
