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Accumulation of Recessive Lethal Mutations in Saccharomyces cerevisiae mlh1 Mismatch Repair Mutants Is Not Associated With Gross Chromosomal Rearrangements
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Accumulation of Recessive Lethal Mutations in Saccharomyces cerevisiae mlh1 Mismatch Repair Mutants Is Not Associated With Gross Chromosomal Rearrangements
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Journal Article
Accumulation of Recessive Lethal Mutations in Saccharomyces cerevisiae mlh1 Mismatch Repair Mutants Is Not Associated With Gross Chromosomal Rearrangements
2006
Overview
We examined mismatch repair (MMR)-defective diploid strains of budding yeast grown for ∼160 generations to determine whether decreases in spore viability due to the uncovering of recessive lethal mutations correlated with an increase in gross chromosomal rearrangements (GCRs). No GCRs were detected despite dramatic decreases in spore viability, suggesting that frameshift and/or other unrepaired DNA replication lesions play a greater role than chromosomal instability in decreasing viability in MMR-defective strains.
Publisher
Genetics Soc America,Genetics Society of America,Copyright © 2006 by the Genetics Society of America
Subject
Adaptor Proteins, Signal Transducing
/ Base Pair Mismatch - genetics
/ E coli
/ Frameshift Mutation - physiology
/ Gene Rearrangement - physiology
/ Genes, Recessive - physiology
/ Genetics
/ Genomics
/ Mutation
/ Nucleic Acid Hybridization - methods
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae Proteins
/ Yeasts
