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Brain-Derived Neurotrophic Factor Modulates Hippocampal Synaptic Transmission by Increasing N-methyl-D-Aspartic Acid Receptor Activity
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Brain-Derived Neurotrophic Factor Modulates Hippocampal Synaptic Transmission by Increasing N-methyl-D-Aspartic Acid Receptor Activity
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Journal Article
Brain-Derived Neurotrophic Factor Modulates Hippocampal Synaptic Transmission by Increasing N-methyl-D-Aspartic Acid Receptor Activity
1998
Overview
Neurotrophins (NTs) have recently been found to regulate synaptic transmission in the hippocampus. Whole-cell and single-channel recordings from cultured hippocampal neurons revealed a mechanism responsible for enhanced synaptic strength. Specifically, brain-derived neurotrophic factor augmented glutamate-evoked, but not acetylcholine-evoked, currents 3-fold and increased N-methyl-D-aspartic acid (NMDA) receptor open probability. Activation of trkB NT receptors was critical, as glutamate currents were not affected by nerve growth factor or NT-3, and increased open probability was prevented by the tyrosine kinase inhibitor K-252a. In addition, the NMDA receptor antagonist MK-801 blocked brain-derived neurotrophic factor enhancement of synaptic transmission, further suggesting that NTs modulate synaptic efficacy via changes in NMDA receptor function.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences,National Academy of Sciences,The National Academy of Sciences
Subject
/ alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology
/ Animals
/ Brain
/ Brain-Derived Neurotrophic Factor - pharmacology
/ Brain-Derived Neurotrophic Factor - physiology
/ Dizocilpine Maleate - pharmacology
/ Glutamic Acid - pharmacology
/ N methyl D aspartate receptors
/ N-Methylaspartate - pharmacology
/ Nerve Growth Factors - pharmacology
/ Neurons
/ Pipettes
/ Rats
/ Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
/ Receptors, N-Methyl-D-Aspartate - drug effects
/ Receptors, N-Methyl-D-Aspartate - physiology
