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Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPα
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Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPα
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Journal Article
Neural recognition molecules CHL1 and NB-3 regulate apical dendrite orientation in the neocortex via PTPα
2008
Overview
Apical dendrites of pyramidal neurons in the neocortex have a stereotypic orientation that is important for neuronal function. Neural recognition molecule Close Homolog of L1 (CHL1) has been shown to regulate oriented growth of apical dendrites in the mouse caudal cortex. Here we show that CHL1 directly associates with NB‐3, a member of the F3/contactin family of neural recognition molecules, and enhances its cell surface expression. Similar to CHL1, NB‐3 exhibits high‐caudal to low‐rostral expression in the deep layer neurons of the neocortex. NB‐3‐deficient mice show abnormal apical dendrite projections of deep layer pyramidal neurons in the visual cortex. Both CHL1 and NB‐3 interact with protein tyrosine phosphatase α (PTPα) and regulate its activity. Moreover, deep layer pyramidal neurons of PTPα‐deficient mice develop misoriented, even inverted, apical dendrites. We propose a signaling complex in which PTPα mediates CHL1 and NB‐3‐regulated apical dendrite projection in the developing caudal cortex.
Publisher
John Wiley & Sons, Ltd,Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Cell Adhesion Molecules - deficiency
/ Cell Adhesion Molecules - genetics
/ Cell Adhesion Molecules - physiology
/ Cell Adhesion Molecules, Neuronal - deficiency
/ Cell Adhesion Molecules, Neuronal - genetics
/ Cell Adhesion Molecules, Neuronal - physiology
/ Humans
/ Mice
/ Neural Cell Adhesion Molecule L1 - deficiency
/ Neural Cell Adhesion Molecule L1 - genetics
/ Neural Cell Adhesion Molecule L1 - physiology
/ p59fyn
/ Prefrontal Cortex - cytology
/ Prefrontal Cortex - enzymology
/ Prefrontal Cortex - metabolism
/ Receptor-Like Protein Tyrosine Phosphatases, Class 4 - deficiency
/ Receptor-Like Protein Tyrosine Phosphatases, Class 4 - genetics
/ Receptor-Like Protein Tyrosine Phosphatases, Class 4 - physiology
