Asset Details
Do you wish to reserve the book?
The Epidemiology of Cardiovascular Defects, Part 2: A Study Based on Data from Three Large Registries of Congenital Malformations
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The Epidemiology of Cardiovascular Defects, Part 2: A Study Based on Data from Three Large Registries of Congenital Malformations
Do you wish to request the book?
The Epidemiology of Cardiovascular Defects, Part 2: A Study Based on Data from Three Large Registries of Congenital Malformations
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The Epidemiology of Cardiovascular Defects, Part 2: A Study Based on Data from Three Large Registries of Congenital Malformations
2003
Overview
There were three objectives of this study: to investigate possible specificity in the association between specific cardiac defects and chromosomal anomalies; to evaluate ways of categorizing cardiac defects into larger groups with epidemiological similarities that could indicate similarities in etiology or pathogenesis; and to analyze the relationship between specific cardiac defects and diabetes. We pooled data on infants (aged 1 year or younger) with congenital cardiovascular defects from three large birth defect registries in California, Sweden, and France. The registries in Sweden and France obtained data through reporting from various sources; in California, medical records were reviewed. For severe congenital heart defects, the percentage of infants with identified chromosomal anomalies varied between 0.9% for d-TGV to 68.4% for ECD. In general, specific cardiac conditions have different risk factors. For example, conotruncal defects have been traditionally grouped, but the data presented in this paper indicates more differences for risk factors for the components of conotruncal defects: tetralogy of Fallot, d-TGV, common truncus, and DORV. In general, we suggest the strategy of \"splitting\" rather than \"lumping\" when searching for specific genetic factors and/or teratogens. Adequate analysis thus requires large registries or collaboration among registries. The findings did not support constellations between mothers' diabetes and specific defects.
Publisher
Springer,Springer Nature B.V
Subject
Abnormalities, Drug-Induced - etiology
/ Adult
/ Anticonvulsants - adverse effects
/ Chromosome Aberrations - statistics & numerical data
/ Female
/ Gynaecology, Obstetrics and Reproductive Medicine
/ Gynekologi, obstetrik och reproduktionsmedicin
/ Heart Defects, Congenital - chemically induced
/ Heart Defects, Congenital - epidemiology
/ Heart Defects, Congenital - etiology
/ Heart Defects, Congenital - genetics
/ Humans
/ Infant
/ Lithium Compounds - adverse effects
/ Male
/ Pregnancy in Diabetics - complications
