Journal Article

Simian immunodeficiency virus-specific CD4+ T cells from successful vaccinees target the SIV Gag capsid

Wilson, Nancy A, Loffredo, John T, Watkins, David I, Erickson, Priscilla, Rudersdorf, Richard, Giraldo-Vela, Juan P, Bean, Alex T, Wallace, Lyle T

2010

Overview

We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (amino acids 249-291). We have also defined the major histocompatibility complex class II (MHC-II) restricting alleles for several of these responses and show that DQ-restricted CD4+ T-cells depend on unique combinations of both the DQA and DQB alleles. Analysis of SIV-specific CD4+ T-cell responses elicited by a successful vaccine may have important implications in the understanding of vaccine design.

• Publisher: Berlin/Heidelberg : Springer-Verlag,Springer-Verlag,Springer Nature B.V
• Subject: Allergology / Amino Acid Sequence / Amino acids / Animals / Antigens / Biomedical and Life Sciences / Biomedicine / Brief Communication / CD4-positive T-lymphocytes / CD4-Positive T-Lymphocytes - immunology / Cell Biology / Epitopes / Epitopes - immunology / Gene Function / Gene Products, gag / Gene Products, gag - immunology / Genes, MHC Class II / genetics / Histocompatibility Antigens Class II / Histocompatibility Antigens Class II - immunology / HIV / Human Genetics / Immune system / Immunologic Memory / Immunology / Infections / isolation & purification / Macaca mulatta / Macaca mulatta - genetics / Macaca mulatta - immunology / major histocompatibility complex / Mamu-MHC / Molecular Sequence Data / Peptide Fragments / Peptide Fragments - immunology / Peptides / physiology / prevention & control / Retroviridae Proteins / Retroviridae Proteins - immunology / Rhesus macaques / SAIDS Vaccines / SAIDS Vaccines - immunology / Simian Acquired Immunodeficiency Syndrome / Simian Acquired Immunodeficiency Syndrome - immunology / Simian Acquired Immunodeficiency Syndrome - prevention & control / Simian Immunodeficiency Virus / Simian Immunodeficiency Virus - immunology / Simian Immunodeficiency Virus - isolation & purification / Simian Immunodeficiency Virus - physiology / SIV / T-Lymphocyte Subsets / T-Lymphocyte Subsets - immunology / Vaccination / Vaccines / Viral Load / Viremia / Viremia - immunology / Viremia - prevention & control / Virus Replication