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NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
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NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
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Journal Article
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
2012
Overview
Glutamatergic neurotransmission mediated by N -methyl- d -aspartate (NMDA) receptors is vital for the cortical computations underlying cognition and might be disrupted in severe neuropsychiatric illnesses such as schizophrenia. Studies on this topic have been limited to processes in local circuits; however, cognition involves large-scale brain systems with multiple interacting regions. A prominent feature of the human brain’s global architecture is the anticorrelation of default-mode vs. task-positive systems. Here, we show that administration of an NMDA glutamate receptor antagonist, ketamine, disrupted the reciprocal relationship between these systems in terms of task-dependent activation and connectivity during performance of delayed working memory. Furthermore, the degree of this disruption predicted task performance and transiently evoked symptoms characteristic of schizophrenia. We offer a parsimonious hypothesis for this disruption via biophysically realistic computational modeling, namely cortical disinhibition. Together, the present findings establish links between glutamate’s role in the organization of large-scale anticorrelated neural systems, cognition, and symptoms associated with schizophrenia in humans.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Brain
/ Excitatory Amino Acid Antagonists - administration & dosage
/ Excitatory Amino Acid Antagonists - pharmacology
/ Female
/ Humans
/ ketamine
/ Ketamine - administration & dosage
/ Male
/ Memory
/ N methyl D aspartate receptors
/ Neurons
/ Pattern Recognition, Visual - drug effects
/ Pattern Recognition, Visual - physiology
/ Placebos
/ Psychomotor Performance - drug effects
/ Psychomotor Performance - physiology
/ Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
/ Receptors, N-Methyl-D-Aspartate - physiology
/ Schizophrenia - physiopathology
/ Synaptic Transmission - drug effects
