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Expression of Syndecan-4 and Correlation with Metastatic Potential in Testicular Germ Cell Tumours
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Expression of Syndecan-4 and Correlation with Metastatic Potential in Testicular Germ Cell Tumours
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Journal Article
Expression of Syndecan-4 and Correlation with Metastatic Potential in Testicular Germ Cell Tumours
2013
Overview
Although syndecan-4 is implicated in cancer progression, there is no information for its role in testicular germ cell tumours (TGCTs). Thus, we examined the expression of syndecan-4 in patients with TGCTs and its correlation with the clinicopathological findings. Immunohistochemical staining in 71 tissue specimens and mRNA analysis revealed significant overexpression of syndecan-4 in TGCTs. In seminomas, high percentage of tumour cells exhibited membranous and/or cytoplasmic staining for syndecan-4 in all cases. Stromal staining for syndecan-4 was found in seminomas and it was associated with nodal metastasis (P=0.04), vascular/lymphatic invasion (P=0.01), and disease stage (P=0.04). Reduced tumour cell associated staining for syndecan-4 was observed in nonseminomatous germ cell tumours (NSGCTs) compared to seminomas. This loss of syndecan-4 was associated with nodal metastasis (P=0.01), vascular/lymphatic invasion (P=0.01), and disease stage (P=0.01). Stromal staining for syndecan-4 in NSGCTs did not correlate with any of the clinicopathological variables. The stromal expression of syndecan-4 in TGCTs was correlated with microvessel density (P=0.03). Our results indicate that syndecan-4 is differentially expressed in seminomas and NSGCTs and might be a useful marker. Stromal staining in seminomas and reduced levels of syndecan-4 in tumour cells in NSGCTs are related to metastatic potential, whereas stromal staining in TGCTs is associated with neovascularization.
Publisher
Hindawi Publishing Corporation,John Wiley & Sons, Inc
Subject
/ Adult
/ Aged
/ Humans
/ Male
/ Medicine
/ Neoplasms, Germ Cell and Embryonal - blood supply
/ Neoplasms, Germ Cell and Embryonal - metabolism
/ Neoplasms, Germ Cell and Embryonal - pathology
/ Reverse Transcriptase Polymerase Chain Reaction
/ Testicular Neoplasms - blood supply
/ Testicular Neoplasms - metabolism
/ Testicular Neoplasms - pathology
/ Tumors
