Journal Article

Recent trends and impact of localized surface plasmon resonance (LSPR) and surface-enhanced Raman spectroscopy (SERS) in modern analysis

Ganti, Subrahmanya S., Nanda, Bibhu Prasad, Bhatia, Rohit, Rani, Priyanka, Paul, Priyanka, Aman

2024

Overview

An optical biosensor is a specialized analytical device that utilizes the principles of optics and light in bimolecular processes. Localized surface plasmon resonance (LSPR) is a phenomenon in the realm of nanophotonics that occurs when metallic nanoparticles (NPs) or nanostructures interact with incident light. Conversely, surface-enhanced Raman spectroscopy (SERS) is an influential analytical technique based on Raman scattering, wherein it amplifies the Raman signals of molecules when they are situated near specific and specially designed nanostructures. A detailed exploration of the recent ground-breaking developments in optical biosensors employing LSPR and SERS technologies has been thoroughly discussed along with their underlying principles and the working mechanisms. A biosensor chip has been created, featuring a high-density deposition of gold nanoparticles (AuNPs) under varying ligand concentration and reaction duration on the substrate. An ordinary description, along with a visual illustration, has been thoroughly provided for concepts such as a sensogram, refractive index shift, surface plasmon resonance (SPR), and the evanescent field, Rayleigh scattering, Raman scattering, as well as the electromagnetic enhancement and chemical enhancement. LSPR and SERS both have advantages and disadvantages, but widely used SERS has some advantages over LSPR, like chemical specificity, high sensitivity, multiplexing, and versatility in different fields. This review confirms and elucidates the significance of different disease biomarker identification. LSPR and SERS both play a vital role in the detection of various types of cancer, such as cervical cancer, ovarian cancer, endometrial cancer, prostate cancer, colorectal cancer, and brain tumors. This proposed optical biosensor offers potential applications for early diagnosis and monitoring of viral disease, bacterial infectious diseases, fungal diseases, diabetes, and cardiac disease biosensing. LSPR and SERS provide a new direction for environmental monitoring, food safety, refining impurities from water samples, and lead detection. The understanding of these biosensors is still limited and challenging. [Display omitted] •Optical biosensors offer crucial insights into molecular interactions with their precise and sensitive detection capabilities.•We discussed plasmonic mode hybridization and multiresonant features in SERS enhance its sensitivity, contributing to advanced bio-plasmonics.•Recent progress in designing plasmonic hotspots for SERS involves a comparative analysis of fabrication techniques.•Exploring broad applications of LSPR and SERS, with ongoing advancements, challenges, and promising future prospects.

• Publisher: Elsevier B.V,Xi'an Jiaotong University, Journal of Pharmaceutical Analysis,Department of Pharmaceutical Analysis,ISF College of Pharmacy Moga,142001,Punjab,India%Department of Pharmaceutical Chemistry,ISF College of Pharmacy Moga,142001,Punjab,India%Department of Pharmaceutical Analysis,ISF College of Pharmacy Moga,142001,Punjab,India,Department of Pharmaceutical Chemistry,ISF College of Pharmacy Moga,142001,Punjab,India,Elsevier
• Subject: Agricultural production / Biomarker / Biomarkers / Biosensors / Brain tumors / Cancer / Cervical cancer / Colorectal cancer / Coronary artery disease / Diabetes mellitus / Disease / Environmental monitoring / Gold / Heart diseases / Impurities / Infectious diseases / Ligands / Light / Localized surface plasmon resonance / Nanoparticles / Nanophotonic / Optics / Ovarian cancer / Prostate cancer / Raman spectroscopy / Sensors / Spectrum analysis / Surface plasmon resonance / Surface-enhanced Raman spectroscopy / Uterine cancer / Viral diseases