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Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications
Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications
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Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications
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Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications
Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications
Journal Article

Stimuli‐Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications

2022
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Overview
Infections are regarded as the most severe complication associated with human health, which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic platforms for antibacterial treatments, which provide great potential for accurate theranostics. In this review, the advantages, the response mechanisms, and the key design principles of stimuli‐responsive antibacterial materials are highlighted. The biomedical applications, the current challenges, and future directions of stimuli‐responsive antibacterial materials are also discussed. First, the categories of stimuli‐responsive antibacterial materials are comprehensively itemized based on different sources of stimuli, including external physical environmental stimuli (e.g., temperature, light, electricity, salt, etc.) and bacterial metabolites stimuli (e.g., acid, enzyme, redox, etc.). Second, structural characteristics, design principles, and biomedical applications of the responsive materials are discussed, and the underlying interrelationships are revealed. The molecular structures and design principles are closely related to the sources of stimuli. Finally, the challenging issues of stimuli‐responsive materials are proposed. This review will provide scientific guidance to promote the clinical applications of stimuli‐responsive antibacterial materials. This review systematically summarizes the advantages, the response mechanisms, and the key design principles of stimuli‐responsive antibacterial materials. The biomedical applications, the current challenges, and development trends of stimuli‐responsive antibacterial materials are also discussed. Stimuli‐responsive antibacterial materials are appealing to achieve intelligent and personalized medicine, that can avoid the formation of biofilm and inhibit the emergence of drug‐resistant bacteria.