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Wireless Non‐Invasive Monitoring of Cholesterol Using a Smart Contact Lens
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Wireless Non‐Invasive Monitoring of Cholesterol Using a Smart Contact Lens
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Journal Article
Wireless Non‐Invasive Monitoring of Cholesterol Using a Smart Contact Lens
2022
Overview
Herein, a wireless and soft smart contact lens that enables real‐time quantitative recording of cholesterol in tear fluids for the monitoring of patients with hyperlipidemia using a smartphone is reported. This contact lens incorporates an electrochemical biosensor for the continuous detection of cholesterol concentrations, stretchable antenna, and integrated circuits for wireless communication, which makes a smartphone the only device required to operate this lens remotely without obstructing the wearer's vision. The hyperlipidemia rabbit model is utilized to confirm the correlation between cholesterol levels in tear fluid and blood and to confirm the feasibility of this smart contact lens for diagnostic application of cholesterol‐related diseases. Further in vivo tests with human subjects demonstrated its good biocompatibility, wearability, and reliability as a non‐invasive healthcare device. The authors present the soft smart contact lens that can detect cholesterol levels in tear fluids. This smart contact lens consists of an electrochemical cholesterol biosensor, an antenna, and a near‐field communication chip. This device shows stable cholesterol detection and portability. In addition, the cholesterol correlation between tear and blood is confirmed using rabbit models and human studies.
