Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Design and rationale of the TOTAL trial: A randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI

by Avezum, Alvaro , Rokoss, Michael , Cairns, John , Pancholy, Samir B. , Cheema, Asim N. , Džavík, Vladimír , Steg, Philippe Gabriel , Moreno, Raul , Gershlick, Anthony , Bhindi, Ravinay , Meeks, Brandi , Niemelä, Kari , Yusuf, Salim , Shestakovska, Olga , Jolly, Sanjit S. , Rao, Sunil V. , Cantor, Warren J. , Welsh, Robert C. , Lavi, Shahar , Thabane, Lehana , Bertrand, Olivier F.

in Blood clots / Blood pressure / Cardiology / Cardiovascular / Catheters / Clinical outcomes / Combined Modality Therapy / Enzymes / Heart attacks / Heart failure / Humans / Hypotheses / Medical imaging / Microcirculation / Mortality / Myocardial Infarction - therapy / Percutaneous Coronary Intervention - methods / Prospective Studies / Stroke / Suction - methods / Thrombectomy - methods / Thrombosis / Treatment Outcome

2014

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

2014

Confirm

Do you wish to request the book?

2014

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Design and rationale of the TOTAL trial: A randomized trial of routine aspiration ThrOmbecTomy with percutaneous coronary intervention (PCI) versus PCI ALone in patients with ST-elevation myocardial infarction undergoing primary PCI

Avezum, Alvaro,

Rokoss, Michael,

Cairns, John,

Pancholy, Samir B.,

Cheema, Asim N.,

Džavík, Vladimír,

Steg, Philippe Gabriel,

Moreno, Raul,

Gershlick, Anthony,

Bhindi, Ravinay,

Meeks, Brandi,

Niemelä, Kari,

Yusuf, Salim,

Shestakovska, Olga,

Jolly, Sanjit S.,

Rao, Sunil V.,

Cantor, Warren J.,

Welsh, Robert C.,

Lavi, Shahar,

Thabane, Lehana,

Bertrand, Olivier F.

2014

Overview

A major limitation of primary percutaneous coronary intervention (PPCI) for the treatment of ST-elevation myocardial infarction (STEMI) is impaired microvascular perfusion due to embolization and obstruction of microcirculation with thrombus. Manual thrombectomy has the potential to reduce distal embolization and improve microvascular perfusion. Clinical trials have shown mixed results regarding thrombectomy. The objective of this study is to evaluate the efficacy of routine upfront manual aspiration thrombectomy during PPCI compared with percutaneous coronary intervention alone in patients with STEMI. This is a multicenter, prospective, open, international, randomized trial with blinded assessment of outcomes. Patients with STEMI undergoing PPCI are randomized to upfront routine manual aspiration thrombectomy with the Export catheter (Medtronic CardioVascular, Santa Rosa, CA) or to percutaneous coronary intervention alone. The primary outcome is the composite of cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or new or worsening New York Heart Association class IV heart failure up to 180 days. The trial uses an event-driven design and will recruit 10,700 patients. The TOTAL trial will determine the effect of routine manual aspiration thrombectomy during PPCI on clinically important outcomes.

Share this book

Add to My Shelf

Publisher

Elsevier Inc,Elsevier Limited

Subject

/ Combined Modality Therapy