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Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects
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Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects
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Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects
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Journal Article
Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects
2014
Overview
Background
The use of insulin-sensitizing drugs has been shown to improve both the reproductive and the metabolic aspects of PCOS. However, the mechanisms by which metformin exerts its effects in PCOS are still not completely understood. There is growing evidence of a direct effect of metformin on ovarian steroidogenesis, independent of its effects on insulin sensitivity.
Methods
We evaluated the short-term effects of metformin compared to placebo on basal and LH- stimulated androgen secretion as well as on hormonal and metabolic parameters in 19 women with PCOS during a four-day randomized, double-blinded placebo-controlled clinical trial. In a three month follow-up evaluation, we investigated the longer-term therapeutic effects of metformin on ovulation, metabolic and endocrine parameters.
Results
Compared to placebo, 2 days of metformin was associated with a borderline significant reduction in the free androgen index (FAI) (p = 0.05) and with a reduction in the serum concentration of LH-stimulated testosterone (T) (p = 0.03). Following three months of use, a decline in serum T was observed, independent of changes in weight, metabolic parameters, or insulin sensitivity.
Conclusions
In women with PCOS, Metformin induces a prompt decrease in LH-stimulated T secretion after only several days of use. This action precedes the medication’s effects on insulin sensitivity or weight loss.
Publisher
BioMed Central,BioMed Central Ltd
Subject
/ Adrenal Cortex - physiopathology
/ Adult
/ Diabetes
/ Female
/ Glucose
/ Humans
/ Hyperandrogenism - prevention & control
/ Hyperinsulinism - prevention & control
/ Hypoglycemic Agents - adverse effects
/ Hypoglycemic Agents - therapeutic use
/ Insulin
/ Luteinizing Hormone - antagonists & inhibitors
/ Luteinizing Hormone - genetics
/ Medical equipment and supplies industry
/ Medicine
/ Polycystic Ovary Syndrome - complications
/ Polycystic Ovary Syndrome - drug therapy
/ Polycystic Ovary Syndrome - metabolism
/ Polycystic Ovary Syndrome - physiopathology
/ Recombinant Proteins - chemistry
/ Recombinant Proteins - genetics
/ Studies
/ Women
