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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
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Journal Article
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
2001
Overview
The transcription factor C/EBPα (for CCAAT/enhancer binding protein-α; encoded by the gene
CEBPA
) is crucial for the differentiation of granulocytes. Conditional expression of C/EBPα triggers neutrophilic differentiation, and no mature granulocytes are observed in
Cebpa
-mutant mice. Here we identify heterozygous mutations in
CEBPA
in ten patients with acute myeloid leukemia (AML). We found that five mutations in the amino terminus truncate the full-length protein, but did not affect a 30-kD protein initiated further downstream. The mutant proteins block wild-type C/EBPα DNA binding and transactivation of granulocyte target genes in a dominant-negative manner, and fails to induce granulocytic differentiation. Ours is the first report of
CEBPA
mutations in human neoplasia, and such mutations are likely to induce the differentiation block found in AML.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animal Genetics and Genomics
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ CCAAT-Enhancer-Binding Protein-alpha - biosynthesis
/ CCAAT-Enhancer-Binding Protein-alpha - chemistry
/ CCAAT-Enhancer-Binding Protein-alpha - genetics
/ CCAAT/enhancer binding protein-^a
/ Cell Differentiation - genetics
/ Complications and side effects
/ Hematologic and hematopoietic diseases
/ Humans
/ Leukemia, Myeloid, Acute - genetics
/ Leukemia, Myeloid, Acute - metabolism
/ Leukemia, Myeloid, Acute - pathology
/ Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
/ Mutation
