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Chemotherapy-induced damage to ovary: mechanisms and clinical impact
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Journal Article
Chemotherapy-induced damage to ovary: mechanisms and clinical impact
2016
Overview
Cancer is a major public health problem around the world. Currently, about 5% of women diagnosed with cancer are of reproductive age. These young survivors may face compromised fertility. The effects of chemotherapeutic agents on ovarian reserve and its clinical consequences are generally inferred from a variety of surrogate markers of ovarian reserve, all aiming to provide prognostic information on fertility or the likelihood of success of infertility treatment. Until recently, the mechanisms that are responsible for chemotherapy-induced ovarian damage were not fully elucidated. The understanding of these mechanisms may lead to targeted treatments to preserve fertility. In this manuscript, we will review the current knowledge on the mechanism of ovarian damage and clinical impact of chemotherapy agents on fertility.
Publisher
Future Medicine Ltd
Subject
/ Aging
/ Antineoplastic Agents - adverse effects
/ Antineoplastic Agents - therapeutic use
/ DNA
/ Female
/ follicle-stimulating hormone
/ Humans
/ Infertility, Female - diagnosis
/ Infertility, Female - etiology
/ Infertility, Female - therapy
/ Lymphoma
/ Ovarian Follicle - drug effects
/ Ovarian Follicle - metabolism
/ Ovarian Follicle - pathology
/ Ovarian Reserve - drug effects
/ Review
/ Risk
