Asset Details
Do you wish to reserve the book?
Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan
Do you wish to request the book?
Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan
2016
Overview
Background
A previous multicenter prospective randomized study from Japan showed that
Helicobacter pylori
eradication reduced the development of metachronous gastric cancer (MGC) after endoscopic resection for early gastric cancer. MGC risk, however, is not eliminated; yet few studies have evaluated its long-term incidence and risk factors. In this study, we investigated the incidence of and risk factors for MGC in patients who underwent endoscopic resection for early gastric cancer with successful
H. pylori
eradication.
Methods
A total of 594 patients who underwent endoscopic resection for early gastric cancer and successful
H. pylori
eradication at three institutions (National Cancer Center Hospital, University of Tokyo Hospital, and Wakayama Medical University Hospital) were analyzed retrospectively. Annual endoscopic surveillance was performed after initial endoscopic resection. MGC was defined as a gastric cancer newly detected at least 1 year after successful
H. pylori
eradication.
Results
Ninety-four MGCs were detected in 79 patients during the 4.5-year median follow-up period. Kaplan–Meier analysis showed the cumulative incidence of MGC 5 years after successful
H. pylori
eradication was 15.0 %; the incidence of MGC calculated by use of the person-year method was 29.9 cases per 1000 person-years. Multivariate analysis using the Cox proportional hazards model revealed that male sex, severe gastric mucosal atrophy, and multiple gastric cancers before successful
H. pylori
eradication were independent risk factors for MGC. Eleven percent of MGCs (10 of 94) were detected more than 5 years after successful
H. pylori
eradication.
Conclusion
Surveillance endoscopy for MGC in patients who have undergone endoscopic resection for early gastric cancer should be performed even after successful
H. pylori
eradication.
Publisher
Springer Japan,Springer Nature B.V
Subject
/ Adult
/ Aged
/ Female
/ Gastrectomy - adverse effects
/ Helicobacter Infections - complications
/ Helicobacter Infections - virology
/ Humans
/ Male
/ Medicine
/ Neoplasms, Second Primary - epidemiology
/ Neoplasms, Second Primary - etiology
/ Neoplasms, Second Primary - pathology
/ Neoplasms, Second Primary - surgery
/ Oncology
/ Stomach Neoplasms - epidemiology
/ Stomach Neoplasms - etiology
