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European Guidelines Concerning the Transplantation of Organs from Donors with a History of Breast Cancer
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European Guidelines Concerning the Transplantation of Organs from Donors with a History of Breast Cancer
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Journal Article
European Guidelines Concerning the Transplantation of Organs from Donors with a History of Breast Cancer
2023
Overview
Dear Editor, The Council of Europe (CoE), based in Strasbourg (France), is an international organization that promotes cooperation among European countries in the areas of human rights, democracy, rule of law, culture and public health. A history of breast cancer (BC) has a prominent place in the debate concerning the transplantation of human organs. Some subtypes are associated with almost no risk of metastases, such as low-grade ductal carcinoma in situ (DCIS), while others are highly proliferative with a particularly unfavorable prognosis in the short term, such as triple negative BC, and others have a risk of late re-evolution, sometimes decades after the diagnosis, for example invasive lobular carcinoma. [...]before deciding on the clinical use of organs obtained from a woman with a past or current history of BC, it is essential to know the BC prognosis based on its histological subtype, molecular characteristics, including expression of hormone receptors, human epidermal growth factor-receptor 2 and proliferation index, together with stage, completeness of treatment, time since the diagnosis and regularity and normality of follow-up. The EDQM has now reconsidered the criteria for acceptance of organs from donors with a history of BC, acknowledging the key role of medical teams in performing a risk-benefit assessment for each particular case. Since BC has high potential for late and aggressive recurrence and metastases, even after many years of complete remission, patients with BC should only be accepted as organ donors with the highest caution and for very selected recipients. [...]donor examination for BC recurrence and/or metastases, including careful clinical examination and imaging, is necessary even after a long disease-free survival.
Publisher
Galenos Publishing House,Galenos Publishing
