Journal Article

Epstein‐Barr virus strain variation and cancer

Kanda, Teru, Yajima, Misako, Ikuta, Kazufumi

2019

Overview

Epstein‐Barr virus (EBV) is a human tumor virus and is etiologically linked to various malignancies. Certain EBV‐associated diseases, such as Burkitt lymphomas and nasopharyngeal carcinomas, are endemic and exhibit biased geographic distribution worldwide. Recent advances in deep sequencing technology enabled high‐throughput sequencing of the EBV genome from clinical samples. Rapid cloning and sequencing of cancer‐derived EBV genomes, followed by reconstitution of infectious virus, have also become possible. These developments have revealed that various EBV strains are differentially distributed throughout the world, and that the behavior of cancer‐derived EBV strains is different from that of the prototype EBV strain of non‐cancerous origin. In this review, we summarize recent progress and future perspectives regarding the association between EBV strain variation and cancer. Recent advances in deep sequencing technology enabled high‐throughput sequencing of the EBV genome from clinical samples. We summarize recent progress and future perspectives regarding the association between EBV strain variation and cancer.

• Publisher: John Wiley & Sons, Inc,John Wiley and Sons Inc
• Subject: Animals / Antigens / Artificial chromosomes / Cancer / Carcinoma / Cell Transformation, Viral / Deoxyribonucleic acid / Disease / DNA / DNA methylation / Epstein-Barr virus / Epstein-Barr Virus Infections - epidemiology / Epstein-Barr Virus Infections - virology / Genes / Genetic Variation / Genome, Viral / Genomes / Genomics - methods / geographic distribution / Geographical distribution / Herpesvirus 4, Human - classification / Herpesvirus 4, Human - physiology / Human papillomavirus / Humans / Infections / Lymphoma / MicroRNAs / nasopharyngeal carcinoma / Neoplasms - etiology / Proteins / R&D / Research & development / Review / sequencing / strain variation / Strains (organisms)