Asset Details
Do you wish to reserve the book?
Association between hemostatic changes and contusion volume in traumatic brain injury: an observational cohort study
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Association between hemostatic changes and contusion volume in traumatic brain injury: an observational cohort study
Do you wish to request the book?
Association between hemostatic changes and contusion volume in traumatic brain injury: an observational cohort study
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Association between hemostatic changes and contusion volume in traumatic brain injury: an observational cohort study
2026
Overview
Purpose
Contusion expansion is a key determinant of outcome after traumatic brain injury (TBI). Because many patients develop acute coagulopathy, it has been proposed that hemostatic changes may drive this expansion, but the link remains uncertain.
Methods
In this retrospective single-center cohort, we included adults with isolated moderate-to-severe TBI and no pre-injury antithrombotic therapy. The hemostatic markers activated partial thromboplastin time (APTT), prothrombin time (PT, reported as INR), platelet count (PLT), and fibrinogen were measured on admission and during the first 72 h. Contusion volumes were derived from serial CT scans. Associations between hemostatic markers and contusion volumes over time were analyzed using generalized additive mixed models (GAMMs), adjusting for confounders.
Results
Among 109 patients, median admission values were fibrinogen 2.4 g/L, PT-INR 1.0, APTT 29 s, and PLT 233 × 10
9
/L. After admission, fibrinogen and PLT declined, whereas PT-INR and APTT increased modestly. Contusion volume increased from a median of 0.7 ml at baseline to 4.6 ml on the third CT. In univariable models, higher APTT and PT-INR values and lower platelet counts were associated with larger contusion volumes, but these associations lost significance after adjustment for age and time from injury.
Conclusion
Hemostatic disturbances, as measured by standard coagulation assays, were common after TBI but not independently associated with contusion volume over time.
Publisher
Springer Vienna,Springer Nature B.V,Springer
Subject
/ Aged
/ Brain Contusion - diagnostic imaging
/ Brain Injuries, Traumatic - blood
/ Brain Injuries, Traumatic - complications
/ Brain Injuries, Traumatic - diagnostic imaging
/ Brain Injuries, Traumatic - pathology
/ Coma
/ Female
/ Hematoma
/ Humans
/ International Normalized Ratio
/ Male
/ Medicine
/ Patients
/ Trauma
