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The role of gastric mucins and mucin‐related glycans in gastric cancers
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The role of gastric mucins and mucin‐related glycans in gastric cancers
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The role of gastric mucins and mucin‐related glycans in gastric cancers
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Journal Article
The role of gastric mucins and mucin‐related glycans in gastric cancers
2024
Overview
Gastric mucins serve as a protective barrier on the stomach's surface, protecting from external stimuli including gastric acid and gut microbiota. Their composition typically changes in response to the metaplastic sequence triggered by Helicobacter pylori infection. This alteration in gastric mucins is also observed in cases of gastric cancer, although the precise connection between mucin expressions and gastric carcinogenesis remains uncertain. This review first introduces the relationship between mucin expressions and gastric metaplasia or cancer observed in humans and mice. Additionally, we discuss potential pathogenic mechanisms of how aberrant mucins and their glycans affect gastric carcinogenesis. Finally, we summarize challenges to target tumor‐specific glycans by utilizing lectin‐drug conjugates that can bind to specific glycans. Understanding the correlation and mechanism between these mucin expressions and gastric carcinogenesis could pave the way for new strategies in gastric cancer treatment. Gastric mucins shield the stomach lining from acid and bacteria, with alterations seen in Helicobacter pylori infection and gastric cancer. The review explores this relationship, potential mechanisms in carcinogenesis, and challenges in targeting tumor‐specific glycans for treatment, offering insights into novel approaches for gastric cancer therapy.
