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Polarized sorting and trafficking in epithelial cells
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Journal Article
Polarized sorting and trafficking in epithelial cells
2012
Overview
The polarized distribution of proteins and lipids at the surface membrane of epithelial cells results in the forma- tion of an apical and a basolateral domain, which are separated by tight junctions. The generation and maintenance of epithelial polarity require elaborate mechanisms that guarantee correct sorting and vectorial delivery of cargo molecules. This dynamic process involves the interaction of sorting signals with sorting machineries and the forma- tion of transport carriers. Here we review the recent advances in the field of polarized sorting in epithelial cells. We especially highlight the role of lipid rafts in apical sorting.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
