Journal Article

The effect of soy isoflavone on bone mineral density in postmenopausal Taiwanese women with bone loss: a 2-year randomized double-blind placebo-controlled study

Chen, C. L., Wang, S. Y., Wu, J. S., Peng, H. Y., Wu, C. H., Tsai, K. S., Tu, S. T., Tai, T. Y., Chang, C. I., Shaw, N. S.

2012

Overview

Summary The treatment of 300-mg/day isoflavones (aglycone equivalents) (172.5 mg genistein + 127.5 mg daidzein) for 2 years failed to prevent lumbar spine and total proximal femur bone mineral density (BMD) from declining as compared with the placebo group in a randomized, double-blind, two-arm designed study enrolling 431 postmenopausal women 45–65 years old. Introduction This study evaluated the effects of soy isoflavones on bone metabolism in postmenopausal women. Methods Four hundred and thirty-one women, aged 45–65 years, orally consumed 300-mg/day isoflavones (aglycone equivalents) or a placebo for 2 years in a parallel group, randomized, double-blind, two-arm study. Each participant also ingested 600 mg of calcium and 125 IU of vitamin D 3 per day. The BMD of the lumbar spine and total proximal femur were measured using dual-energy X-ray absorptiometry at baseline and every half-year thereafter. Serum bone-specific alkaline phosphatase, urinary N-telopeptide of type 1 collagen/creatinine, and other safety assessments were examined regularly. Results Two hundred out of 217 subjects in the isoflavone group and 199 out of 214 cases in placebo group completed the treatment. Serum concentrations of isoflavone metabolites, genistein and daidzein, of the intervention group were remarkably elevated following intake of isoflavones ( p  < 0.001). However, differences in the mean percentage changes of BMD throughout the treatment period were not statistically significant (lumbar spine, p  = 0.42; total femur, p  = 0.39) between the isoflavone and placebo groups, according to the generalized estimating equation (GEE) method. A significant time trend of bone loss was observed at both sites as assessed by the GEE method following repeated measurement of BMD ( p  < 0.001). Differences in bone marker levels were not significant between the two treatment groups. Conclusion Treatment with 300-mg/day isoflavones (aglycone equivalents) failed to prevent a decline in BMD in the lumbar spine or total femur compared with the placebo group.

• Publisher: Springer-Verlag,Springer Nature B.V
• Subject: Absorptiometry, Photon - methods / Aglycones / Alkaline phosphatase / Bone density / Bone Density - drug effects / Bone Density Conservation Agents - adverse effects / Bone Density Conservation Agents - pharmacology / Bone Density Conservation Agents - therapeutic use / Bone loss / Bone mineral density / Bone turnover / Calcium / Collagen / Creatinine / daidzein / Double-Blind Method / Drug Administration Schedule / Drug Combinations / Dual energy X-ray absorptiometry / Endocrinology / Female / Femur / Femur - physiopathology / Genistein - adverse effects / Genistein - pharmacology / Genistein - therapeutic use / Humans / Isoflavones / Isoflavones - adverse effects / Isoflavones - pharmacology / Isoflavones - therapeutic use / Lumbar Vertebrae - physiopathology / Mathematical models / Medicine / Medicine & Public Health / Menopause / Metabolites / Middle Aged / Original / Original Article / Orthopedics / Osteoporosis, Postmenopausal - drug therapy / Osteoporosis, Postmenopausal - physiopathology / Phytochemicals / Phytoestrogens - adverse effects / Phytoestrogens - pharmacology / Phytoestrogens - therapeutic use / Placebos / Post-menopause / Rheumatology / Soy products / Soybeans / Spine (lumbar) / Statistical analysis / Treatment Outcome / Vitamin D3 / Women