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Effect of infectious bursal disease (IBD) vaccine on Salmonella Enteritidis infected chickens
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Effect of infectious bursal disease (IBD) vaccine on Salmonella Enteritidis infected chickens
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Journal Article
Effect of infectious bursal disease (IBD) vaccine on Salmonella Enteritidis infected chickens
2017
Overview
•Effect of IBD vaccine (228E®) on S. Enteritidis infected chickens was indicated.•The recorded mortalities were higher in the 228E®+SE infected group.•The anti-S. Enteritidis antibody titres were higher in the SE infected group.•The 228E®+SE group had higher bursal lesion scores than the SE infected group.•Chickens given IBDV vaccine failed antibody response to the S. Enteritidis.
Chickens infected with both infectious bursal disease virus (IBDV) and Salmonella had higher mortality. In this work, we investigated the effect of IBDV vaccine (modified live-virus bursal disease vaccine, Nobilis strain 228E®) on experimentally infected chickens with Salmonella Enteritidis (SE).
Four experimental groups were included in this study, negative control group, 228E®group, 228E®+SE infected group, and SE infected group. Chickens were ocularly administrated 228E® at 12days of age and orally infected with S. Enteritidis at 13days of age. Sera, intestinal fluid, blood, cloacal swabs and tissue samples were collected at 1, 2 and 3weeks post vaccination (PV).
The recorded mortalities were higher in the 228E®+SE infected group, compared to the SE infected group. The anti-S. Enteritidis serum antibody titer and the intestinal mucosal IgA level were higher in the SE infected group at 2 and 3weeks PV, compared to 228E®+SE infected group. S. Enteritidis fecal shedding and organ colonization were significantly higher in the 228E®+SE infected group than the SE infected group at 2 and 3weeks PV. The 228E®+SE group had significantly lower bursa to body weight ratios at 2 and 3weeks PV, as well as had higher bursal lesion scores than the SE infected group. IBDV vaccine depressed the specific-SE systemic and mucosal antibody responses, but did not affect the specific-SE cellular immune responses.
Chickens administrated IBDV vaccine, followed by S. Enteritidis infection, could cause a significant effect on the bursa of Fabricius, resulting in failure of systemic and mucosal antibody responses to the S. Enteritidis and reduce the elimination and the clearance of S. Enteritidis.
Publisher
Elsevier Ltd,Elsevier Limited
Subject
/ Animals
/ Birnaviridae Infections - complications
/ Birnaviridae Infections - mortality
/ Birnaviridae Infections - prevention & control
/ Birnaviridae Infections - veterinary
/ Blood
/ Chickens
/ cloaca
/ Coinfection - prevention & control
/ Immune response (cell-mediated)
/ Infectious bursal disease virus
/ Infectious bursal disease virus - immunology
/ Infectious bursal disease virus vaccine
/ Mucosa
/ Poultry
/ Poultry Diseases - mortality
/ Poultry Diseases - prevention & control
/ Salmonella Infections, Animal - complications
/ Salmonella Infections, Animal - mortality
/ Shedding
/ Vaccines
/ Viral Vaccines - administration & dosage
/ Viral Vaccines - adverse effects
/ Viruses
