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Production of Active Oxygen Species by Blood Phagocytes of Pregnant Women and Their Newborns with Intrauterine Infection
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Production of Active Oxygen Species by Blood Phagocytes of Pregnant Women and Their Newborns with Intrauterine Infection
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Journal Article
Production of Active Oxygen Species by Blood Phagocytes of Pregnant Women and Their Newborns with Intrauterine Infection
2013
Overview
We studied the relationship between changes in the maternal and newborn granulocyte functions under conditions of infection risk and realization. Women with normal gestation and their healthy newborns, pregnant women with a high risk of infection and their newborns, healthy or with intrauterine infection, were examined. Changes in the active oxygen species dependent phagocytosis system were found in the blood of risk group patients. An inverse relationship between the parameters venous and umbilical cord blood was detected indicating a relationship between changes in functional activities of maternal and newborn granulocytes. The percentage of CD11b
+
cells in venous and umbilical cord blood strictly correlated with the percent of cells that phagocytosed FITC-labeled
E. coli
. Deviations in the generation of active oxygen species in phagocytosis seemed to be related to the expression of surface receptors in the risk groups.
Publisher
Springer US,Springer,Springer Nature B.V
Subject
/ Adult
/ Biomedical and Life Sciences
/ Communicable Diseases - blood
/ Communicable Diseases - immunology
/ Communicable Diseases - pathology
/ Escherichia coli - chemistry
/ Escherichia coli - immunology
/ Female
/ Fluorescein-5-isothiocyanate
/ GPI-Linked Proteins - genetics
/ GPI-Linked Proteins - immunology
/ Humans
/ Pregnancy Complications, Infectious - blood
/ Pregnancy Complications, Infectious - immunology
/ Pregnancy Complications, Infectious - pathology
/ Pregnancy Complications, Infectious - surgery
/ Reactive Oxygen Species - blood
/ Women
