Journal Article

Children with obesity have poorer circadian health as assessed by a global circadian health score

Ríos, Rafael, Martínez-Lozano, Nuria, Salmerón, Diego, Garaulet, Marta, Rodríguez-Martín, María, Gris-Peñas, Antonio, Santaclara-Maneiro, Vicente, Tvarijonaviciute, Asta

2024

Overview

Background Circadian health refers to individuals’ well-being and balance in terms of their circadian rhythm. It is influenced by external cues. In adults, a close relationship between circadian-related alterations and obesity has been described. However, studies in children are scarce, and circadian health and its association with obesity have not been evaluated globally. We aimed to assess whether circadian health differed between children with and without obesity as determined by a global circadian score (GCS) in a school-age population. Methods Four hundred and thirty-two children (7–12 years) were recruited in Spain. Non-invasive tools were used to calculate the GCS: (1) 7-day rhythm of wrist temperature (T), activity (A), position (P), an integrative variable that combines T, A, and P (TAP); (2) cortisol; and (3) 7-day food and sleep records. Body mass index, body fat percentage, waist circumference (WC), melatonin concentration, and cardiometabolic marker levels were determined. Results Circadian health, as assessed by the GCS, differed among children with obesity, overweight, and normal weight, with poorer circadian health among children with obesity. Children with obesity and abdominal obesity had 3.54 and 2.39 greater odds of having poor circadian health, respectively, than did those with normal weight or low WC. The percentage of rhythmicity, a marker of the robustness of the TAP rhythm, and the amplitude, both components of the GCS, decreased with increasing obesity. Different lifestyle behaviors were involved in the association between circadian health and obesity, particularly protein intake ( P  = 0.024), physical activity level ( P  = 0.076) and chronotype ( P  = 0.029). Conclusions The GCS can capture the relationship between circadian health and obesity in school-age children. Protein intake, physical activity level, and chronotype were involved in this association. Early intervention based on improving circadian health may help to prevent childhood obesity.

• Publisher: Springer Nature Singapore,Springer Nature B.V,Department of Physiology,Regional Campus of International Excellence,University of Murcia,30100 Murcia,CP,Spain,Biomedical Research Institute of Murcia,IMIB-Arrixaca-UMU,University Clinical Hospital,30120 Murcia,Spain,Health and Social Sciences Department,University of Murcia,Murcia,Spain,Consortium for Biomedical Research in Epidemiology and Public Health,Madrid,Spain%Interdisciplinary Laboratory of Clinical Analysis(Interlab-UMU),University of Murcia,Murcia,Spain%Department of Physiology,Regional Campus of International Excellence,University of Murcia,30100 Murcia,CP,Spain,Division of Sleep and Circadian Disorders,Brigham and Women's Hospital(BWH),and Division of Sleep Medicine,Harvard Medical School,Boston,MA 02115,USA,Biomedical Research Institute of Murcia,IMIB-Arrixaca-UMU,University Clinical Hospital,30120 Murcia,Spain%Health Area of Lorca,Lorca,Murcia,Spain%Biomedical Research Institute of Murcia,IMIB-Arrixaca-UMU,University Clinical Hospital,30120 Murcia,Spain
• Subject: Behavior / Body fat / Body mass index / Circadian rhythm / Critical Care Medicine / Exercise / Health care / Hormones / Imaging / Intensive / Maternal and Child Health / Medicine / Medicine & Public Health / Melatonin / Obesity / Original / Original Article / Parents & parenting / Pediatric Surgery / Pediatrics / Radiology / Sleep / Surgery / Variables