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CORM ‐ A1 delivers carbon monoxide to the kidney and alleviates post‐ischemic renal dysfunction in rat and swine models
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CORM ‐ A1 delivers carbon monoxide to the kidney and alleviates post‐ischemic renal dysfunction in rat and swine models
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Journal Article
CORM ‐ A1 delivers carbon monoxide to the kidney and alleviates post‐ischemic renal dysfunction in rat and swine models
2025
Overview
Carbon monoxide (CO), a gas endogenously produced in mammalian tissues, exerts vasodilatory, anti‐ischemic, and anti‐inflammatory effects. These properties have prompted the development of CO‐releasing molecules (CO‐RMs) for therapeutic purposes. Among this class of compounds is CORM‐A1, a boron‐based carboxylic acid, which generates controlled amounts of CO under physiological conditions. In this proof‐of‐principle study we explored the potential of CORM‐A1 to protect kidneys from warm ischemia and reperfusion (WI/R) injury in rat and swine models. We found that intravenous administration of CORM‐A1 significantly increased blood carboxyhemoglobin (COHb) levels while facilitating CO accumulation in renal tissue, thus confirming its ability to deliver CO to peripheral organs. In rats subjected to 45‐ and 60‐min WI/R, administration of CORM‐A1 improved renal function at reperfusion, as shown by decreased serum creatinine and urea levels. Histopathological analysis revealed substantial protection against tubular damage, cell infiltration, and inflammation, especially after 60‐min ischemia. Protection was dose‐dependent, with higher doses offering enhanced effects. In a swine kidney auto‐transplantation model, CORM‐A1 significantly improved graft function, reduced fibrosis and necrosis, and extended graft survival. These findings position CORM‐A1 as a promising CO prodrug, with translational relevance for clinical applications in kidney transplantation and other ischemia‐related conditions.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
/ Animals
/ Boron
/ Carbon Monoxide - administration & dosage
/ Carbon Monoxide - metabolism
/ CORM‐A1
/ Fibrosis
/ Hogs
/ Ischemia
/ Kidneys
/ Male
/ Organometallic Compounds - administration & dosage
/ Organometallic Compounds - pharmacology
/ Original
/ Rats
/ Reperfusion Injury - drug therapy
/ Reperfusion Injury - pathology
/ Reperfusion Injury - prevention & control
/ Swine
