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Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

by Milosavljevic, Dejan , Christiansen, Mikael , Teunissen, Charlotte , Leurs, Cyra , Vecchio, Domizia , Vercellino, Marco , Deisenhammer, Florian , Gaetani, Lorenzo , Petersen, Thor , Berek, Klaus , Rosenstein, Igal , Cavalla, Paola , Di Filippo, Massimiliano , Hassler, Michaela , Schnabl, Christine , Emeršič, Andreja , Presslauer, Stefan , Rot, Uroš , van Pesch, Vincent , Hegen, Harald

in Agreements / Blood / Cerebrospinal fluid / Demographics / diagnosis / Immunoassay / Immunoglobulins / Immunology / Isoelectric focusing / kappa free light chain / Leukocytes / Light chains / Males / Multiple sclerosis / Neurosciences / Neurovetenskaper / primary progressive / sensitivity

2023

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Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

2023

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Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

2023

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Journal Article

Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

Milosavljevic, Dejan,

Christiansen, Mikael,

Teunissen, Charlotte,

Leurs, Cyra,

Vecchio, Domizia,

Vercellino, Marco,

Deisenhammer, Florian,

Gaetani, Lorenzo,

Petersen, Thor,

Berek, Klaus,

Rosenstein, Igal,

Cavalla, Paola,

Di Filippo, Massimiliano,

Hassler, Michaela,

Schnabl, Christine,

Emeršič, Andreja,

Presslauer, Stefan,

Rot, Uroš,

van Pesch, Vincent,

Hegen, Harald

2023

Overview

Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS). To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB). Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation. A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients. κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.

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Frontiers Media SA,Frontiers Media S.A

Subject

Agreements

/ Blood

/ Cerebrospinal fluid