Asset Details
Do you wish to reserve the book?
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
Do you wish to request the book?
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
2019
Overview
Public health interventions to control the current epidemic of carbapenem-resistant
Klebsiella pneumoniae
rely on a comprehensive understanding of its emergence and spread over a wide range of geographical scales. We analysed the genome sequences and epidemiological data of >1,700
K. pneumoniae
samples isolated from patients in 244 hospitals in 32 countries during the European Survey of Carbapenemase-Producing Enterobacteriaceae. We demonstrate that carbapenemase acquisition is the main cause of carbapenem resistance and that it occurred across diverse phylogenetic backgrounds. However, 477 of 682 (69.9%) carbapenemase-positive isolates are concentrated in four clonal lineages, sequence types 11, 15, 101, 258/512 and their derivatives. Combined analysis of the genetic and geographic distances between isolates with different β-lactam resistance determinants suggests that the propensity of
K. pneumoniae
to spread in hospital environments correlates with the degree of resistance and that carbapenemase-positive isolates have the highest transmissibility. Indeed, we found that over half of the hospitals that contributed carbapenemase-positive isolates probably experienced within-hospital transmission, and interhospital spread is far more frequent within, rather than between, countries. Finally, we propose a value of 21 for the number of single nucleotide polymorphisms that optimizes the discrimination of hospital clusters and detail the international spread of the successful epidemic lineage, ST258/512.
Genomic and epidemiological analysis of carbapenem-resistant
Klebsiella pneumoniae
across Europe finds increased transmissibility of four clonal lineages, especially between hospitals within countries.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Carbapenem-Resistant Enterobacteriaceae - classification
/ Carbapenem-Resistant Enterobacteriaceae - genetics
/ Cross Infection - epidemiology
/ Cross Infection - transmission
/ Enterobacteriaceae Infections - epidemiology
/ Enterobacteriaceae Infections - transmission
/ Genomes
/ Humans
/ Polymorphism, Single Nucleotide
/ Single-nucleotide polymorphism
/ Virology
