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Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence
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Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence
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Journal Article
Macroevolution of gastric Helicobacter species unveils interspecies admixture and time of divergence
2018
Overview
Since the discovery of the human pathogen
Helicobacter pylori
, various other
Helicobacter
species have been identified in the stomach of domesticated and wild mammals. To better understand the evolutionary history of these ecologically similar but genetically distinct species, we analyzed 108 gastric
Helicobacter
genomes and included 54 enterohepatic
Helicobacter
genomes for comparison purposes. An admixture analysis supported the presence of an ecological barrier, preventing the genetic exchange between the gastric and enterohepatic
Helicobacter
species, and unraveled many gene flow events within and across species residing in the stomach. As pets can be colonized by multiple gastric
Helicobacter
species, the genetic exchange between the canine and feline strains was evident, with
H. heilmannii
and
H. bizzozeronii
showing the highest interspecies recombination. An admixture between
H. pylori
(in particular, the ancestral African strains),
H. acinonychis
from wild felines and
H. cetorum
from marine mammals was also identified. Because these latter species do not share the same host, this phenomenon is most likely a remaining signal of shared ancestry. A reconstruction of the time of divergence of the gastric
Helicobacter
spp. revealed that the domestic animal-related
Helicobacter
species evolved in parallel with
H. pylori
and its two closest relatives (
H. acinonychis
and
H. cetorum
), rather than together.
Publisher
Nature Publishing Group UK,Oxford University Press
Subject
/ 45/23
/ 45/43
/ 692/420
/ Animals
/ Biomedical and Life Sciences
/ Cats
/ Dogs
/ Ecology
/ Genomes
/ Helicobacter - classification
/ Helicobacter - isolation & purification
/ Helicobacter Infections - microbiology
/ Helicobacter Infections - veterinary
/ Humans
/ Microbial Genetics and Genomics
/ Pets
/ Species
/ Stomach
/ Zoonoses
