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Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge
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Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge
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Journal Article
Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge
2009
Overview
Drs. Cesar Arias and Barbara Murray write that we have arrived at a point as frightening as the preantibiotic era: for patients infected with multidrug-resistant bacteria, there is no magic bullet.
In March 1942, a 33-year-old woman lay dying of streptococcal sepsis in a New Haven, Connecticut, hospital, and despite the best efforts of contemporary medical science, her doctors could not eradicate her bloodstream infection. Then they managed to obtain a small amount of a newly discovered substance called penicillin, which they cautiously injected into her. After repeated doses, her bloodstream was cleared of streptococci, she made a full recovery, and she went on to live to the age of 90.
1
Sixty-six years after her startling recovery, a report
2
described a 70-year-old man in San Francisco with endocarditis caused by vancomycin-resistant . . .
Publisher
Massachusetts Medical Society
Subject
/ Drug Resistance, Multiple, Bacterial - genetics
/ Enterococcus faecium - drug effects
/ Enterococcus faecium - pathogenicity
/ Gram-Negative Bacteria - pathogenicity
/ Gram-Negative Bacterial Infections - drug therapy
/ Humans
/ Methicillin-Resistant Staphylococcus aureus - genetics
/ Methicillin-Resistant Staphylococcus aureus - pathogenicity
/ Mutation
