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Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
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Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
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Journal Article
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
2017
Overview
Mechanisms that ensure and maintain the stability of genetic information are fundamentally important for organismal function and can have a large impact on disease, aging, and life span. While a multi-layered cellular apparatus exists to detect and respond to DNA damage, various insults from environmental and endogenous sources continuously affect DNA integrity. Over time this can lead to the accumulation of somatic mutations, which is thought to be one of the major causes of aging. We have previously found that overexpression of the essential human DNA repair and splicing factor SNEV, also called PRP19 or hPso4, extends replicative life span of cultured human endothelial cells and impedes accumulation of DNA damage. Here, we show that adult-specific overexpression of
dPrp19
, the
D. melanogaster
ortholog of human SNEV/PRP19/hPso4, robustly extends life span in female fruit flies. This increase in life span is accompanied by reduced levels of DNA damage and improved resistance to oxidative and genotoxic stress. Our findings suggest that
dPrp19
plays an evolutionarily conserved role in aging, life span modulation and stress resistance, and support the notion that superior DNA maintenance is key to longevity.
Aging: Living longer by improving DNA repair
Increasing levels of DNA repair factor Prp19 in fruit flies extends their life span and protects against stress. Prp19 is a protein that is present in a wide range of organisms and enables human endothelial cells to live longer in vitro. In this article, an international team of scientists from Austria, Germany and Switzerland found that higher Prp19 levels also prolong the life span of a whole organism in fruit flies, reduce DNA damage and increase survival when exposed to DNA damaging compounds. In contrast to female flies, males were unaffected. Their findings support the long-held view that repair of DNA damage, one of the hallmarks of aging, is key to longevity. They also provide an intriguing but poorly understood connection between cellular aging and the survival of whole organisms.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
