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A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly
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A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly
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Journal Article
A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly
2021
Overview
The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles. However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding site in the immature Gag lattice. IP6 also promotes formation of the mature capsid protein (CA) lattice via a second IP6 binding site, and enhances core stability, creating a favorable environment for reverse transcription. IP6 also enhances assembly of other retroviruses, from both the Lentivirus and the Alpharetrovirus genera. These findings suggest that IP6 may have a conserved function throughout the family Retroviridae. Here, we discuss the different steps in the viral life cycle that are influenced by IP6, and describe in detail how IP6 interacts with the immature and mature lattices of different retroviruses.
Publisher
MDPI AG,MDPI
Subject
/ E coli
/ Gag
/ gag Gene Products, Human Immunodeficiency Virus - genetics
/ gag Gene Products, Human Immunodeficiency Virus - metabolism
/ Genomes
/ HIV
/ Human immunodeficiency virus
/ Human Immunodeficiency Virus Proteins - metabolism
/ Inositol
/ Mutation
/ Proteins
/ Retroviridae Proteins - metabolism
/ Review
