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Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts
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Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts
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Journal Article
Eleutheroside B, a selective late sodium current inhibitor, suppresses atrial fibrillation induced by sea anemone toxin II in rabbit hearts
2021
Overview
Eleutheroside B (EB) is the main active constituent derived from the Chinese herb
Acanthopanax senticosus
(AS) that has been reported to possess cardioprotective effects. In this study we investigated the effects of EB on cardiac electrophysiology and its suppression on atrial fibrillation (AF). Whole-cell recording was conducted in isolated rabbit atrial myocytes. The intracellular calcium ([Ca
2+
]
i
) concentration was measured using calcium indicator Fura-2/AM fluorescence. Monophasic action potential (MAP) and electrocardiogram (ECG) synchronous recordings were conducted in Langendorff-perfused rabbit hearts using ECG signal sampling and analysis system. We showed that EB dose-dependently inhibited late sodium current (
I
NaL
), transient sodium current (
I
NaT
), and sea anemone toxin II (ATX II)-increased
I
NaL
with IC
50
values of 167, 1582, and 181 μM, respectively. On the other hand, EB (800 μM) did not affect L-type calcium current (
I
CaL
), inward rectifier potassium channel current (
I
K
), and action potential duration (APD). Furthermore, EB (300 μM) markedly decreased ATX II-prolonged the APD at 90% repolarization (APD
90
) and eliminated ATX II-induced early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and triggered activities (TAs). Moreover, EB (200 μM) significantly suppressed ATX II-induced Na
+
-dependent [Ca
2+
]
i
overload in atrial myocytes. In the Langendorff-perfused rabbit hearts, application of EB (200 μM) or TTX (2 μM) substantially decreased ATX II-induced incidences of atrial fibrillation (AF), ventricular fibrillation (VF), and heart death. These results suggest that augmented
I
NaL
alone is sufficient to induce AF, and EB exerts anti-AF actions mainly via blocking
I
NaL
, which put forward the basis of pharmacology for new clinical application of EB.
Publisher
Springer Singapore,Nature Publishing Group
Subject
/ Action Potentials - drug effects
/ Animals
/ Atrial Fibrillation - prevention & control
/ Biomedical and Life Sciences
/ Cardiotonic Agents - administration & dosage
/ Cardiotonic Agents - pharmacology
/ Dose-Response Relationship, Drug
/ EKG
/ Fura-2
/ Glucosides - administration & dosage
/ Heart
/ Myocytes
/ Myocytes, Cardiac - drug effects
/ Myocytes, Cardiac - metabolism
/ Phenylpropionates - administration & dosage
/ Phenylpropionates - pharmacology
/ Rabbits
/ Sodium
/ Sodium Channel Blockers - administration & dosage
/ Sodium Channel Blockers - pharmacology
/ Vaccine
