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Encapsulating peritoneal sclerosis outcomes: a retrospective study on the significance of nutritional parameter variations
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Encapsulating peritoneal sclerosis outcomes: a retrospective study on the significance of nutritional parameter variations
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Journal Article
Encapsulating peritoneal sclerosis outcomes: a retrospective study on the significance of nutritional parameter variations
2025
Overview
Background
Encapsulating peritoneal sclerosis (EPS) can result in abdominal organ encasement, and bowel obstruction, and is associated with a high mortality rate. While various risk factors have been identified for the development of EPS, the factors influencing patient outcomes in EPS are less well-studied. This study aims to investigate the prognostic factors that affect the clinical course and survival of EPS patients.
Methods
In this retrospective study, we examined a cohort of 1406 peritoneal dialysis (PD) patients over an 18-year study period. Among them, 35 individuals were diagnosed with EPS. We collected data encompassing demographic characteristics, comorbidities, PD-related parameters, clinical symptoms, computed tomography scores, laboratory results, and treatment modalities. The survival analysis incorporated both univariate and multivariate Cox regression models, as well as the Kaplan-Meier method.
Results
Patients with EPS exhibited a spectrum of clinical symptoms, with intestinal obstruction occurring in 88.6% and ultrafiltration failure in 42.9%. The five-year survival rate was 26.3%, and malnutrition and gastrointestinal infections contributed to three-fourths of the deaths. A notable finding was the one-month drop in albumin levels as a marker of ongoing malabsorption, demonstrating its predictive value for both overall (HR 2.01,
p
= 0.042) and EPS-related (HR 2.79,
p
= 0.017) mortality.
Conclusions
This study emphasizes the crucial role of monitoring the one-month albumin drop after EPS diagnosis, providing valuable insights for the improvement of clinical management and patient care.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Aged
/ Albumin
/ Complications and side effects
/ Continuous ambulatory peritoneal dialysis
/ Encapsulating peritoneal sclerosis
/ Female
/ Humans
/ Intestinal Obstruction - etiology
/ Male
/ Medicine
/ Patients
/ Peritoneal Dialysis - adverse effects
/ Peritoneal Fibrosis - diagnosis
/ Peritoneal Fibrosis - etiology
/ Peritoneal Fibrosis - mortality
/ Peritoneal Fibrosis - therapy
/ Survival
