Journal Article

Diagnosis of Autism Spectrum Disorder (ASD) by Dynamic Functional Connectivity Using GNN-LSTM

Zhang, Zixi, Xiao, Liuming, Tang, Jun, Hu, Miaojun, Hu, Yao, Chen, Jie

2025

Overview

Early detection of autism spectrum disorder (ASD) is particularly important given its insidious qualities and the high cost of the diagnostic process. Currently, static functional connectivity studies have achieved significant results in the field of ASD detection. However, with the deepening of clinical research, more and more evidence suggests that dynamic functional connectivity analysis can more comprehensively reveal the complex and variable characteristics of brain networks and their underlying mechanisms, thus providing more solid scientific support for computer-aided diagnosis of ASD. To overcome the lack of time-scale information in static functional connectivity analysis, in this paper, we proposes an innovative GNN-LSTM model, which combines the advantages of long short-term memory (LSTM) and graph neural networks (GNNs). The model captures the spatial features in fMRI data by GNN and aggregates the temporal information of dynamic functional connectivity using LSTM to generate a more comprehensive spatio-temporal feature representation of fMRI data. Further, a dynamic graph pooling method is proposed to extract the final node representations from the dynamic graph representations for classification tasks. To address the variable dependence of dynamic feature connectivity on time scales, the model introduces a jump connection mechanism to enhance information extraction between internal units and capture features at different time scales. The model achieves remarkable results on the ABIDE dataset, with accuracies of 80.4% on the ABIDE I and 79.63% on the ABIDE II, which strongly demonstrates the effectiveness and potential of the model for ASD detection. This study not only provides new perspectives and methods for computer-aided diagnosis of ASD but also provides useful references for research in related fields.

• Publisher: MDPI AG,MDPI
• Subject: Accuracy / Algorithms / Autism / autism spectrum disorder (ASD) / Autism Spectrum Disorder - diagnosis / Autism Spectrum Disorder - diagnostic imaging / Autism Spectrum Disorder - physiopathology / Brain - diagnostic imaging / Brain - physiopathology / Brain research / Datasets / Diagnosis / Diagnosis, Computer-Assisted - methods / dynamic functional connectivity / graph neural networks (GNNs) / Humans / long short-term memory (LSTM) / Magnetic Resonance Imaging - methods / Medical research / Medicine, Experimental / Neural networks / Neural Networks, Computer / Time series