Journal Article

CT and MRI-based door-needle-times for acute stroke patients a quasi-randomized clinical trial

Hansen, Christine Krarup, Christensen, Anders, Havsteen, Inger, Nybing, Janus, Kaasbøl, Mari-Anne, Christensen, Hanne, Rodgers, Helen, Kruuse, Christina

2017

Overview

•First randomized trial comparing thrombolytic treatment-delay for CT versus MRI-examined acute stroke patients.•The trial is based on a comprehensive number of consecutive patients and was conducted in a well-established stroke-unit.•MRI was not feasible in 48.9% of MRI-allocated.•CT-based thrombolysis in acute stroke patients is significantly faster compared with MRI-based assessment.•MR-based assessment of acute stroke patients prior to intravenous treatment is a potential option in the acute stroke setting. Door-Needle-times (DNT) of 20min are feasible when Computer Tomography (CT) is used for first-line brain-imaging to assess stroke-patients’ eligibility for intravenous-tissue-Plasminogen-Activator (iv-tPA), but the more time-consuming Magnetic Resonance Imaging (MRI)-based-evaluation is superior in detecting acute ischaemia.

• Publisher: Elsevier B.V,Elsevier Limited
• Subject: Aged / Clinical trials / Computed tomography / Female / Humans / Intravenous administration / Ischemia / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Magnetic Resonance Imaging - standards / Male / Medical imaging / Needles / Neuroimaging / Neurology / Neurosurgery / NMR / Nuclear magnetic resonance / Patients / Radiology / Stroke / Stroke - diagnostic imaging / Stroke - therapy / Thrombolytic Therapy - methods / Thrombolytic Therapy - standards / Time-to-Treatment - standards / Tomography / Tomography, X-Ray Computed - methods / Tomography, X-Ray Computed - standards