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RNA metabolism in neurodegenerative disease
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Journal Article
RNA metabolism in neurodegenerative disease
2017
Overview
Aging-related neurodegenerative diseases are progressive and fatal neurological diseases that are characterized by irreversible neuron loss and gliosis. With a growing population of aging individuals, there is a pressing need to better understand the basic biology underlying these diseases. Although diverse disease mechanisms have been implicated in neurodegeneration, a common theme of altered RNA processing has emerged as a unifying contributing factor to neurodegenerative disease. RNA processing includes a series of distinct processes, including RNA splicing, transport and stability, as well as the biogenesis of non-coding RNAs. Here, we highlight how some of these mechanisms are altered in neurodegenerative disease, including the mislocalization of RNA-binding proteins and their sequestration induced by microsatellite repeats, microRNA biogenesis alterations and defective tRNA biogenesis, as well as changes to long-intergenic non-coding RNAs. We also highlight potential therapeutic interventions for each of these mechanisms.
Publisher
The Company of Biologists Ltd,The Company of Biologists
Subject
/ Amyotrophic lateral sclerosis
/ Animals
/ Dementia
/ Disease
/ Humans
/ lncRNA
/ miRNA
/ Mutation
/ Neurodegenerative Diseases - genetics
/ Neurodegenerative Diseases - metabolism
/ Neurons
/ Proteins
/ RNA
/ RNA Processing, Post-Transcriptional
/ RNA, Untranslated - genetics
/ RNA-Binding Proteins - metabolism
/ Toxicity
/ tRNA
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