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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

by Ludwig, Andreas , Docherty, Andrew J P , Becherer, J David , Ford, Jill W , Broadway, Neil , Hartmann, Dieter , Conrad, Daniel H , Weskamp, Gisela , Sturgill, Jamie , Sehara-Fujisawa, Atsuko , Swendeman, Steven , Saftig, Paul , Martin, Steve , Blobel, Carl P , Umland, Shelby , Black, Roy A

in ADAM Proteins - immunology / ADAM Proteins - metabolism / ADAM10 Protein / Amyloid Precursor Protein Secretases - immunology / Amyloid Precursor Protein Secretases - metabolism / Animals / Autoimmune diseases / B-Lymphocytes - immunology / B-Lymphocytes - metabolism / Biomedical and Life Sciences / Biomedicine / Electrophoresis, Polyacrylamide Gel / Enzyme-Linked Immunosorbent Assay / Fibroblasts - immunology / Fibroblasts - metabolism / Flow Cytometry / Humans / Immunoblotting / Immunology / Infectious Diseases / Membrane Proteins - immunology / Membrane Proteins - metabolism / Mice / Mice, Knockout / Receptors, IgE - immunology / Receptors, IgE - metabolism / Rheumatoid arthritis / Transfection

2006

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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

2006

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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

2006

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Journal Article

ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

Ludwig, Andreas,

Docherty, Andrew J P,

Becherer, J David,

Ford, Jill W,

Broadway, Neil,

Hartmann, Dieter,

Conrad, Daniel H,

Weskamp, Gisela,

Sturgill, Jamie,

Sehara-Fujisawa, Atsuko,

Swendeman, Steven,

Saftig, Paul,

Martin, Steve,

Blobel, Carl P,

Umland, Shelby,

Black, Roy A

2006

Overview

CD23, the low-affinity immunoglobulin E receptor, is an important modulator of the allergic response and of diseases such as rheumatoid arthritis. The proteolytic release of CD23 from cells is considered a key event in the allergic response. Here we used loss-of-function and gain-of-function experiments with cells lacking or overexpressing candidate CD23-releasing enzymes (ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19 and ADAM33), ADAM-knockout mice and a selective inhibitor to identify ADAM10 as the main CD23-releasing enzyme in vivo . Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies.

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Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

ADAM Proteins - immunology

/ ADAM Proteins - metabolism

/ ADAM10 Protein

/ Amyloid Precursor Protein Secretases - immunology

/ Amyloid Precursor Protein Secretases - metabolism

/ Animals

/ Autoimmune diseases