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Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus
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Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus
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Journal Article
Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus
2012
Overview
Dear Editor, Ethylene gas is a classic phytohormone regulating many aspects of plant development and defense. Molecu- lar and genetic studies have revealed a highly conserved signaling pathway starting from the ER membrane-as- sociated receptors to transcription factors in the nucleus [1]. EIN2 （ETHYLENE INSENSITIVE2） is an essential positive regulator of ethylene signaling in Arabidopsis thaliana, as loss-of-function ein2 mutants are completely insensitive to ethylene [2]. EIN2 encodes a 1 294 amino acid protein that comprises a membrane-spanning amino terminus and a functionally unknown carboxyl terminus [3]. E1N2 was reported to localize at the ER membrane when transiently expressed in tobacco leaf cells [4]. EIN3 （ETHYLENE INSENSITIVE3） and its homolog EIL 1 （EIN3-LIKE 1） are two nuclear-localized transcrip- tion factors genetically acting downstream of EIN2 [5, 6]. However, it remains a long mystery on how the ethyl- ene signal is transmitted from ER-located EIN2 into the nucleus to modulate EIN3/EILl-directed transcription. Here we report that the carboxyl end of E1N2 （CEND） is a trafficking signal translocating from ER membrane to the nucleus. Ethylene signal promotes the cleavage of CEND from ER-located E1N2, and facilitates its nuclear localization to stabilize E1N3 protein.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Active Transport, Cell Nucleus
/ Arabidopsis Proteins - chemistry
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Biomedical and Life Sciences
/ Dexamethasone - pharmacology
/ Green Fluorescent Proteins - biosynthesis
/ Green Fluorescent Proteins - genetics
/ Nuclear Localization Signals
/ Receptors, Cell Surface - chemistry
/ Receptors, Cell Surface - genetics
/ Receptors, Cell Surface - metabolism
/ 乙烯气体
/ 介导
/ 信号转导通路
/ 切割
/ 核转位
/ 激活
/ 羧基
/ 转录因子
